Primary progressive aphasia: a window into language neurobiology

André-Roch Lecours Lecture

Amphithéâtre Le Groupe Maurice du CRIUGM, 4545 chemin Queen-Mary, Montréal (Qc) H3W 1W5

Speaker : Stefano Cappa, Professor of Neurology at University School  for Advanced Studies (IUSS) and IRCCS Mondino Foundation, Pavia Italy

The study of Primary Progressive Aphasias (PPA), a group of syndromes due to different neurodegenerative conditions in which the language deficit is relatively selective in the early stages of disease, has both theoretical and clinical relevance. PPA provides an excellent neurological model for the investigation of the neurobiology of language, as the topography of the neuroanatomical degeneration permits to investigate the role in linguistic functions of brain regions seldom affected by ischemic stroke, where lesion location is constrained by the vascular distribution territories. At the clinical level, PPA is a testing ground for non- pharmacological interventions, from speech and language therapy to non-invasive neuromodulation, aiming at a comprehensive management of this relatively rare, but severely disabling condition.

His main areas of expertise are neurodegenerative diseases and the neurobiology of language.