Theme 1 – Neuroscience of Aging at the CRIUGM explores the fundamental and clinical mechanisms of brain aging, whether normal or pathological. Through multidisciplinary approaches and cutting-edge technologies, CRIUGM researchers strive to better understand the biological and cognitive processes of aging in order to develop innovative solutions that enhance brain health and improve the quality of life for older adults.
Key Objectives
- Identify the mechanisms of brain aging : Study biological and cognitive processes, and their interactions, to understand how the brain changes with age.
- Develop advanced biomarkers : Design precise tools to detect neurocognitive disorders at an early stage and monitor their progression.
- Test innovative interventions : Evaluate the effectiveness of strategies such as neurostimulation, cognitive rehabilitation, and digital technology-based approaches.
- Promote translational research : Accelerate the integration of neuroscience discoveries into concrete clinical practices.



Initiatives phares
- Technologies multi-omics et neuroimagerie : Utilisation de données multi-omics, combinées à l’imagerie cérébrale, pour explorer les signatures biologiques associées au vieillissement cérébral.
- Études longitudinales : Suivi de cohortes d’aînés pour comprendre les trajectoires neurocognitives et les facteurs de résilience face au déclin cognitif.
- Projets de neurostimulation : Développement de techniques non invasives visant à ralentir le déclin cognitif ou à améliorer les fonctions cérébrales.
- Collaboration interdisciplinaire : Mobilisation de compétences variées, de la biologie moléculaire à la neuropsychologie, pour une compréhension globale des mécanismes du vieillissement.



Impact et vision
Theme 1 aims to transform our understanding of brain aging and to support the development of concrete solutions for the prevention, diagnosis, and treatment of neurocognitive disorders. Through its work, the CRIUGM continues to strengthen its role as an international leader in neuroscience of aging. The inclusive and collaborative approach adopted by its research teams ensures meaningful outcomes for the scientific community, clinical settings, and older adults alike.
To learn more or explore collaboration opportunities with Theme 1 teams, please contact us.